فاطمه اکبریان

نام و نام خانوادگی: فاطمه اکبریان

مرتبه: استادیار

گروه: علوم پایه / زیست شناسی

 

 

 

 

2013- 2020                   National Institute of Genetic Engineering and Biotechnology                                     Tehran, Iran

                                     Doctoral of Molecular Genetics. GPA: 18.91 /20 & Comprehensive Examination: 19.40 /20.

                                      Dissertation title: Evaluation of dopamine receptor family (D1-D5) gene expression

                                      changes in blood and tissue, and treatment with agonist and antagonist in LNCaP

                                      and PC3 prostate cancer cell lines. Defense date: 2020-01-26.

                                      Supervisor: Professor Ghasem Ahangari

2011 - 2013               Guilan University                                                                                                                Rasht, Iran       Masters of Cellular and Molecular biology. GPA: 19.25 /20.

                                      Thesis title: Investigation of TBX21 -1514 T>C Polymorphism in Iranian Patients

                                      with Multiple Sclerosis. Defense date: 2013-08-28.

                                      Supervisor: Professor Mohammad H. Sanati

2008-2011                 Shahid Beheshti University                                                                                             Tehran, Iran

                                      Bachelors of Cellular and Molecular Biology Minor in Microbiology. GPA: 17.16 /20.

Academic Distinctions

2020                           Ranked 1st among 8 candidates in PhD program, National Institute of Genetic               Tehran, Iran

                                      Engineering and Biotechnology.

2013                                     Ranked 1st Among 21 students in Cellular and Molecular biology MSc program.                    Rasht, Iran

                                      Guilan University.

2003                           Certificate of award from Presidential Education Award Program in recognition       Maryland, USA

                                      of Outstanding Academic Excellence, Julius West School.                                            

Academic Positions

2020- Present            Associate Professor                                                                                                        Tehran, Iran

                                       Ale-Taha Institute of Higher Education

2016- Present              Director of Research and Technology                                                                              Tehran, Iran

                                       Ale-Taha Institute of Higher Education

2015- Present              Founder and Director of Biology Sciences Group                                                          Tehran, Iran

                                     Minors of Genetics, Microbiology, and Biotechnology

                                      Ale-Taha Institute of Higher Education

2014- 2016                   Associate Director of Research and Technology                                                           Tehran, Iran

                                       Ale-Taha Institute of Higher Education

2012– 2013                  National Institute of Genetic Engineering and Biotechnology (NIGEB)                      Tehran, Iran

                                      Research Assistant in Medical Biotechnology Laboratory

Committee work

Sep. 2022                    9^th National Congress of Biology and Natural Resources                                            Tehran, Iran

 President and Scientific Secretary

                                      ISC code: 00220-69388

Jan. 2022                     Workshop on “An Introduction to CRISPR Technology and Applications”               Tehran, Iran

                                      Coordinator and Director

                                       Ale-Taha Institute of Higher Education

Sep. 2021                    National Symposium of “From Knowledge to Technology with an Insight                Tehran, Iran

                                    to Startups” 

                                    Executive chair

August 2021                8^th National Congress of Biology and Natural Resources                                            Tehran, Iran

 Technical program committee member

  ISC code: 00201-93413

August 2021                Introductory and advanced Molecular Techniques Summer School                           Tehran, Iran

                                     Founder and organizer

                                      Ale-Taha Institute of Higher Education

June 2021                    Workshop on “Scientific Writing”                                                                                  Tehran, Iran  

                                     Organizer and Lecturer

                                      Ale-Taha Institute of Higher Education

Apr. 2019                     Workshop on “Gene expression data analysis and visualization”                          Tehran, Iran

                                     Organizer and Lecturer   

                                      National Institute of Genetic Engineering and Biotechnology      

Apr. 2017                     The “1st Symposium of Lipidomics and the effects of Hyperlipidemia”                 Tehran, Iran  

                                  Technical program chair

                                       National Institute of Genetic Engineering and Biotechnology      

2014- 2015                        PLOS ONE Journal reviewer                                                                                                Cambridge, UK

                                     Peer- reviewer of 3 articles

2009-2010                    Shahid Beheshti University                                                                                            Tehran, Iran                                                                                                     

                                     Writer and Editor in Synapse Journal

                                      Technical Quarterly of the Scientific Community of Biology Students

Supervising Experience

2022- Present             Supervisor of MSc. Thesis                                                                                          Tehran, Iran

“Comprehensive bioinformatics analysis to identify tumor microenvironment- related prognostic biomarkers in therapeutic resistant triple- negative breast cancer”

  Reyhaneh Tavanayi

  Ale-Taha Institute of Higher Education 

2022- Present             Supervisor of MSc. Thesis                                                                                          Tehran, Iran

“Identification of novel biomarkers by investigating transcriptomics data through differentially expressed genes in low and high-grade glioma patients”

  Fatemeh Abdi

  Ale-Taha Institute of Higher Education and Royan Institute 

2022- Present             Supervisor of MSc. Thesis                                                                                          Tehran, Iran

“Whole exome sequencing to identify pathogenic mutation(s) in Cardiomyopathy”

   Fatemeh Dina Mokhtari

 Ale-Taha Institute of Higher Education and Iran University Hospital

2022- PresentAdvisorofMSc. Thesis                                                                                       Tehran, Iran

“Investigating the expression level of Bim1 gene in ovarian cancer cell line A2780 by treatment with the alcoholic extract of Galium verum”

 Fatemeh Keshvari

 Ale-Taha Institute of Higher Education and Azad University

2022- Present             Advisor of MSc. Thesis                                                                                                                Tehran, Iran

“Investigating the expression level of SORT 1 gene in ovarian cancer cell line A2780 by treatment with the alcoholic extract of Galium verum”

 Sara Shakeri

 Ale-Taha Institute of Higher Education and Azad University

2021- Present             Supervisor of MSc. Thesis                                                                                          Tehran, Iran

“Molecular design of sgRNA based on CRISPR-Cas13a for diagnosis of SARS-CoV-2

 genome spike region in Iranian patients”

  Maryam Ahmadzadeh

  Ale-Taha Institute of Higher Education and NIGEB                                                                 

2022- 2023                 Advisor of MSc. Thesis                                                                                                                Tehran, Iran

    “Evaluation of N-acetylcysteine effect on the expression level of apoptosis genes

     in granulosa cells in infertile women with endometriosis”

                      Zahra Heshmati

      ROYAN Institute and Ale-Taha Institute of Higher Education                                                            

2022- 2023                 2^nd Supervisor of MSc. Thesis                                                                                                 Tehran, Iran

“Evaluation of the relationship between the level of semen exosomes and quality of

sperm parameters and sperm DNA damage in oligoasthnoteratozoospemia”

Neda Rabooki

  Ghom Medical University and Ale-Taha Institute of Higher Education                                                                

2021- 2023                 Supervisor of MSc. Thesis                                                                                        Tehran, Iran

“Molecular design of sgRNA based on CRISPR-Cas13a for specific detection of

 ORF1ab region in SARS-COV-2 genome infecting Iranian patients”

Fatemeh Farrokhi

  Ale-Taha Institute of Higher Education and NIGEB                                                                 

Teaching Experience

2019- Present                Ale-Taha Institute of Higher Education                                                                          Tehran, Iran     

                                      Advanced Molecular Genetics, Molecular Genetics, English for the Students of Biology

 

2017- 2018                   Ale-Taha Institute of Higher Education                                                                                       Tehran, Iran     

                                      English for the Students of Biology

2016- 2017                   Ale-Taha Institute of Higher Education                                                                                       Tehran, Iran     

                                     Genetics 2, Molecular Genetics, English for the Students of Biology

    

Workshop Attendance

Jul. 2010                       Iran University of Medical Sciences                                                                               Tehran, Iran

                                   Educational Workshop on Molecular Techniques in the Laboratory

Aug. 2010                     Pasteur Summer School                                                                                                  Tehran, Iran

                                      Real-time PCR Course

                                      Eukaryotic Cell Culture Course

                                      Real-time PCR Primer and Probe Design Course

                                      Gene Cloning and Recombinant DNA Technology Course

Aug. 2010                   Pasteur Institute                                                                                                                Tehran, Iran

                                      Endnote Training Workshop

Books

1. The Applications of CRISPR-Cas Technology [ In progress]
2. Quantitative Real- time PCR [Translation Completed, Before Publication].
3. Molecular and Cell Biology of Cancer, 2022.
4. The applications of bioinformatics in medical genetics, 2013, Publication Code: 9786003220430.

Articles

1. Farzaneh Khani, Fatemeh Akbarian, Simin Nafian, Sepideh Mollamohammadi, Shiva Nemati, Hamid Reza Soleimanpour-lichaei, Seyedeh Nafiseh Hassani, Hossein Baharvand, Ghasem Hosseini Salekdeh. Influence of SRY gain-of-function on the survival of rosette neural stem cells derived from human embryonic stem cells [In progress]

2. Fatemeh Akbarian, Maryam Abolhassani, Farid Dadkhah, Farrokh Asadi, and Ghasem Ahangari. Evaluation of TMPRSS2- ERG expression in benign prostatic hyperplasia and prostate cancer patients and its association with dopamine receptors, COMT and IL6 in tumor tissues. [In Progress]

3. Fatemeh Akbarian*, Marziye Poornabi, Sanam Rezazadeh, Fatemeh Hosseini, Solmaz Abolhasanzadeh, 2023. Evaluation of Dipeptidyl peptidase-4 Potential Role for the Management of Inflammation in COVID-19 Patients. [Submitted to Current Respiratory Medicine Reviews Journal].

4. Fatemeh Akbarian*, Fatemeh Abdi, 2022. CRISPR-Based Diagnosis and Treatment of Human Cytomegalovirus (HCMV) Infection. Journal of Biology: Principles to Concepts; Vol.1, issu.1.

5. Maryam Ahmadzadeh, Fatemeh Akbarian, Mohammad Hossein Sanati, 2022. Applications of the novel CRISPR/Cas technology in diagnosis of COVID-19 strains. IACLD Journal; 54: 69-75.

6. Fatemeh Akbarian, Farid Dadkhah, Arezoo Campbell, Farrokh Asadi, and Ghasem Ahangari, 2021. Characterization of dopamine receptor associated drugs on the proliferation and apoptosis of prostate cancer cell lines: Establishing a basis for drug repurposing. Anticancer Agents Med Chem; 21(9):1160-1171.

7. Fatemeh Akbarian, Maryam Abolhassani, Farid Dadkhah, Farrokh Asadi, and Ghasem Ahangari, 2019. Novel insight into differential gene expression and clinical significance of dopamine receptors, COMT, and IL6 in BPH and prostate cancer. Current Molecular Medicine. 19(8).

8. Naghmeh Gholipour, Fatemeh Akbarian, Hamideh Khajeh, Sajjad Ghahhari, Nader Mansour Mousavi, 2018. Mutational Screening of the negative Regulartory Region of Astrocyte Elevated Gene-1 Promoter in Hepatocellular Carcinoma Patients. Journal of Scientific Research and Reports. 20 (6): 1-7.

9. Fatemeh Akbarian, M Ataei, Z Salehi, M Nabavi, MH Sanati, 2018.The protective role of TBX21-1514T>C polymorphism in susceptibility to multiple sclerosis. IJNL. 17(3):111-6.

10. Mitra Ataei, Fatemeh Akbarian, Mahba Ataei Talebi, Peyman Dolati, Maryam Mobaraki, Abolfazl Faraji, Masoud Houshmand, 2018.  Analysis of partial AZFc (gr/gr, b1/b3, and b2/b3) deletions in Iranian oligozoospermia candidates for intracytoplasmic sperm injection (ICSI). Turk J Med Sci; 48: 251-256.

11. Fatemeh Akbarian, Amir Mousavi, Mohammad H. Sanati, Farzaneh Khani, Naghmeh Gholipour, Simin Nafian, 2014. Novel gene delivery systems considering biosafety. Journal of Biosafety, Volume: 7 Issue: 2, PP 79 -94.

12. Bahram Golestani Eimani, Mohammad Hossein Sanati, Seyyed Masoud Houshmand, Mitra Ataei, Fatemeh Akbarian, Naser Shakhssalim, 2014, Expression and Prognostic Significance of Bcl-2 and Bax in the Progression and Clinical Outcome of Transitional Bladder Cell Carcinoma. Cell Journal, 15(4): 274-383.

13. Fatemeh Akbarian, Mohammad Hossein Sanati, 2012. The Role of Mitochondria in Multiple Sclerosis Disease. Genetic-Novin Journal, No.139112.
    

June, 2023      The Effect of N-acetylcysteine on the expression of apoptotic genes in granulosa cells of infertile women with endometriosis. Accepted to be presented at ESHRE 2023 Annual Meeting, Copenhagen, Denmark.

April, 2023      Evaluation of N-acetylcysteine effect on the expression of apoptotic genes in granulosa cells in infertile women with endometriosis. Accepted to be presented at 10th YAZD International Congress and Student Award on Reproductive Medicine Reproductive Medicine and 5th Congress of Reproductive Genetics, Yazd, Iran.

March, 2023   Molecular design of sgRNA based on CRISPR-Cas13a for specific detection of ORF1ab region in SARS-COV-2 genome infecting Iranian patients. 2nd International & 11th Iranian Conference on Bioinformatics, Tehran, Iran.

Nov., 2022    The effect of seminal plasma exosomes on sperm function in oligoasthenoteratoospermia patients. 7th International Conference of Obstetrics: Infertility and Mental Health, Tehran, Iran.

Sep., 2022  CRISPR-based diagnosis of COVID-19 by RdRp gene targeting. The 9th National Conference of Modern Studies in Biology and Natural Sciences, Tehran, Iran.

Sep., 2022      Y chromosome gene profiling in the spontaneous differentiation of human embryonic stem cells into embryoid bodies. The 9th National Conference of Modern Studies in Biology and Natural Sciences, Tehran, Iran.

Sep., 2022     Applications of the isothermal amplification process as a tool for acid nucleic detection in medical sciences and Industry. The 9th National Conference of Modern Studies in Biology and Natural Sciences, Tehran, Iran.

Aug., 2022      An investigation of the SRY expression pattern in embryoid bodies and the effects of SRY overexpression on rosette neural stem cells. 17th National Congress of Biochemistry and 8th International Congress of Biochemistry and Molecular Biology, Tehran, Iran.

Nov., 2021       Personalized treatment of COVID-19 disease as a major breakthrough in the quest for a cure. The 5^th International Congress on Biomedicine, Tehran, Iran.

August, 2021Glutathione and selenium, key players in the activity of unbridled cytokine storms in Covid-19 disease. The 8^th National Congress of Biology and Natural Resources, Tehran, Iran.

August, 2021    Cell Free Synthetic Biology: Definitions, Types and Applications. The 8^th National Congress of Biology and Natural Resources, Tehran, Iran.

August, 2021    Investigation of various epigenetic changes and their role in cancer incidence. The 8^th National Congress of Biology and Natural Resources, Tehran, Iran.

August, 2021       Personalized Medicine: A review on the definitions, applications, and techniques. The 8^th National Congress of Biology and Natural Resources, Tehran, Iran.

August, 2021       Molecular insight into DNA virus infections. The 8^th National Congress of Biology and Natural Resources, Tehran, Iran.

August, 2021    Gene therapy, a hoping strategy for cancer therapy. The 8^th National Congress of Biology and Natural Resources, Tehran, Iran.

August, 2021     Review on different types of gene expression regulation in TATA-less promoter. The 8^th National Congress of Biology and Natural Resources, Tehran, Iran.

August, 2021    Molecular insight into RNA virus infections. The 8^th National Congress of Biology and Natural Resources, Tehran, Iran.

Nov., 2020   Immunological communication between SARS- CoV-2 and dipeptidyl peptidase-4: a possible therapeutic strategy. The 4^th Intl. Congress on Biomedicine, Tehran, Iran.

Nov., 2020    Association of SARS- CoV-2 Infection with Lung Microbial Community. The 4^th International Congress on Biomedicine, Tehran, Iran.

Nov., 2020                  COVID-19 Molecular Crosstalk with Prostate Cancer: Possible Therapeutic Applications. The 4^th International Congress on Biomedicine, Tehran, Iran.

Feb., 2019                  The novel interdisciplinary design to upgrade CAR- T cell technology. The 4^th International Biotechnology Student Conference, Tehran, Iran.

Apr., 2013                   Investigating the Expression of TBX21 Gene in Patients with Multiple Sclerosis: a meta-analysis review. 3^rd Iranian Medical Genetics Congress, Tehran, Iran.

May, 2013                  The genetics of Urinary Bladder Cancer. 16^th Annual IUA Congress, Tehran, Iran.

May, 2013                  The genetics of Prostate Cancer. 16th Annual IUA Congress. Tehran, Iran.

Dec., 2012                  Investigation of -1993 T< C and -1514 T< C polymorphisms in the TBX21 gene in Iranian patients with Multiple Sclerosis. Research and Technology Symposium of the Guilan University. Rasht, Iran.

Nov., 2012      The Role of TBX21 Gene in Multiple Sclerosis. 9^th International MS congress. Tehran, Iran.

May, 2012    The Role of Mitochondria in Multiple Sclerosis Disease.12^th Iranian Genetic Congress. Tehran, Iran.

Certificates of Attendance

Nov. 2017     1^st Symposium of CRISPR Technology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.

Nov. 2012                     9^th International MS Congress, Iran MS Society, Tehran, Iran.

Sep. 2012                     8^thRoyan International Congress on Stem cell biology and Technology, Royan Institute, Tehran, Iran.

May 2012                      12^th Iranian Genetics Congress, Iranian Genetics society, Tehran, Iran.

Jan. 2012        1^st National Congress of Genetics and Biological Resources, Iranian Biological Resource Centre, Tehran, Iran.

Feb. 2010                     National Scholars’ Congress of Conservative Ecology, Shahid Beheshti University, Tehran, Iran.

Laboratory Skills:

1. General: Laboratory and Good Laboratory Practice Techniques
2. Molecular genetic Techniques: cell isolation from PBMC, tissue, and cell line; DNA extraction; RNA extraction; cDNA synthesis; DNA and RNA Quality and Quantity Assays; Primer design; Gel electrophoresis; SSCP; PCR; Real- time quantitative PCR (highly experienced in trouble shooting and setup); familiar with Sanger Sequencing.
3. Cell Techniques: Cancer cell culture techniques; Drug treatments on cell lines and characterizations; MTT assay; double staining immune-fluorescence assay; flow cytometric evaluation of apoptosis and life cycle; cell counting.

Bioinformatics Skills:

1. KEGG and DAVID for Gene set enrichment analysis
2. Linreg and Rest
3. National Center of Biotechnology Information Databases (Pubmed, Nucleotide, Protein, Genome, Gene, uniSTS, EST, SNP, and OMIM)
4. BLAST
5. Oligo7 primer design tool
6. Vector NTI
7. Mega 4
8. CLC main workbench

Reference management skills:

1. EndNote X2
2. Mendeley           

Statistical analysis and data visualization skills:

1. R studio (analysing gene expression data, visualization methods such as various plots, principle component           

analysis, Pearson Correlation Coefficient graph and heatmap)

2.   Graphpad Prism
3.   SPSS
4.   Microsoft Office
5.   Prezi

Language skills:

• Native English speaker, Middle school and high school in Maryland, United States of America
• Native Persian speaker

Interpersonal skills:

1. Attention to detail and ability to work in a team environment
2. Superior organizational skills and highly detail-oriented in carrying-out assignments
3. Willing to learn, energetic with good communication skills
4. Ability to multitask and to work either independently or as a contributing team member in a complex research institution/ clinical environment